Design and Synthesis of Building Blocks for DNA Encoded Libraries

Affinity selection-based screening of large DNA-encoded libraries of lead-like molecules is now a validated method to identify bioactive compounds and it represents the best avenue to interrogate protein targets with the full diversity of available chemicals.

ComInnex provides sets of building blocks (BB) compatible with DNA-encoded chemistry to expand the chemical space accessible and thereby to help our partners to generate more hits against more targets in their lead identification programs. Over the years our custom building blocks and scaffolds have contributed to the synthesis of millions DNA-linked lead-like compounds.

Technology enabled building block examples

Basic DNA encoding strategies