DNA-encoded compound libraries (DELs) became a new inexpensive method for fast and efficent identification of appropriate ligands to target proteins. These kind of libraries consist of organic molecules covalently linked to a unique DNA tag that works as an amplifiable barcode. Our company is focusing on the synthesis of new bi- and trifunctional building blocks that fulfill the nessesary requirements.
Introduction to DNA-encoded Libraries
- extreme-large library sizes ( > 10¹² compounds)
- simpler storage (single test tube)
- easier & cost effective maintenance and usage
- but DNA-compatible chemistry must by applied!
An important part of any DELs is the building block (BB) however there is an acknowledged shortage of BBs for DNA encoded libraries. With the combined usage of rational design and library synthesis experience ComInnex became a leading provider of DNA-encoded Libraries Building Blocks through its Open Collaboration model.
ComInnex’s Building Blocks
- low aromaticity
- high 3D character (fsp3)
- improved physicochemical and ADMET properties (logP, logD, solubility, etc.)
- functional groups accessible towards further chemistry
With the combined usage of rational design and library synthesis experience we have successfully produced a large variety of functionalized Fmoc-protected aminoacid building blocks featuring high-fsp3 character and novelty.