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DEL Toolkit

DEL Toolkit

DNA-Encoded Library Synthesis Services

ComInnex offers specialized DNA Encoded Library (DEL) synthesis services, tailored to our customer’s specific requirements. Using our custom protocols, unique techniques, in-depth know-how and expert resources, we build high-quality libraries for customers, based on their own designs.

A glass bottle vial with DNA_ComInnex

OUR EXPERTISE

SMALL MOLECULE SYNTHESIS 

DNA-COMPATIBLE CHEMISTRY METHODS 

VALIDATION OF BUILDING BLOCKS

Why Choose Us?

 

  • Your unique ideas around DELs, added into your own designed libraries
  • Create libraries where you know what the content is
  • Own the library, to screen several times, or develop further
  • No need for an own DEL synthesis setup

 

 

Customer Benefits

 

  • Fast track for building DELs
  • Turnkey service – we provide all reagents (building blocks, headpiece, DNA-tags)
  • Flexible collaboration model – we create the work processes together, with adaption to your needs
  • High level of quality control – QC levels can be set by you, both ligation and chemical reaction steps are monitored with analytics
  • Follow up services of off-DNA synthesis, lead optimization, etc.

ComInnex pays utmost attention to quality control – ligation efficiency is checked with Agarose gel electrophoresis, and conversions of chemical reactions are verified by LC-MS. The sequence distribution is then verified using next generation sequencing. All information related to the library, including synthesis procedures and quality data, will be transferred along with library samples.

DNA-Encoded Library construction 
Our collection of proprietary DEL Building Blocks extends substantial added value – unique molecules can be built in libraries, to create wide range of diversity.

DEL technology for Drug discovery
We adopt and optimize standard chemical synthetic processes for on-DNA synthesis.

VALIDATION OF BUILDING BLOCKS
The evaluation is performed on DNA ‘headpiece’ and verified by LC-MS.

We accelerate your early drug screening efforts.

Contact us to learn more about where we can help with your DEL molecular library implementation.

DEL Toolkit

BB Designs

Unique BBs Synthesized

On Stock

Resynthesizeable

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