Design and preparation of biologically active small molecule chemical libraries according to customer needs based on in silico prediction and design methods.
ComInnex has developed a Target-Oriented Library (TOL) program recognizing the recent trends and the increasing demand for biology oriented libraries in the pharma industry.
The TOL approach combines state-of-the art chemo-informatics methods:
- data-mining
- 2D/3D similarity search
- fragment-based approaches
- pharmacophore model building
- 3D modelling and docking
- scaffold hopping
Based on multi-year synthetic experience and special technology platform unique drug-like chemical structures generated.
- Special libraries designed and are available for apoptosis induction in cancer cells
- Besides CIX proprietary focused libraries any new compound collections offered and prepared following the requests of the partners
