With decades of experience behind us, our team is brimming with novel chemistry ideas, whilst our design philosophy centers on totally novel yet fully lead-like libraries.
Our bespoke screening sets typically have 100 – 300 members per library in order to sample chemical space effectively and provide medicinal chemists with excellent starting points for further optimization. We use a range of technologies like flow and photochemistry next to in silico modelling and design. Our current libraries concentrate on highly selective hydrogenation transformations to generate novel 3D structures with high Fsp3 characteristics. The concept of our library design has been validated in a collaboration project where ~43,000 compounds have been produced in the last 3 years. We aspire for high-quality so our compounds can be formatted to meet the Lilly MedChem rules as well as the PAINS and QED filters and all undesired and reactive functionalities commonly avoided have been filtered out from libraries.
New Synthesis Technologies
• Selective hydrogenation (bicyclic scaffolds)
• Diastereoselective hydrogenation
• Flow Photochemistry (collaboration with Tim Noel, TUE)
• Flow Negishi Coupling
• SnAP chemistry
• Target Oriented Library