For several years ComInnex has been providing its partners with a range of exclusive and custom made fragments, meaning that our partners can access technology enabled sets of molecules synthesized either from ComInnex intermediates or commercial starting materials. Using our suite of technologies, we can also transform our partners’ intermediates to novel fragments in order to further enhance the proprietary nature of the new compounds to be synthesized.
All virtual fragment sets are filtered using standard criteria (e.g. the rule of 3), but custom filters can also be applied upon request. Typical turnaround time for custom fragment synthesis is 1-2 months, but a range of in-stock fragments are also available for cherry picking.
Furthermore, ComInnex has special expertise in biochemical fragment screening and fragment optimization without structural data. Upon requests we can provide our partners with consulting in these important lead identification tasks.
Technology Enabled Fragment Examples