+36-1-880-8500 info@cominnex.com

    Custom Chemistry

    A team of chemists dedicated to the customer who thrive on a challenge, take pride in their work, communicate openly and efficiently and possess a wealth of experience. The team is backed by state of the art analytical support and has access to a host of technologies including flow and photochemistry instrumentation. The current infrastructure enables our scientists to prepare final targets from mg to 50g scale.

    • Our team of highly skilled chemists has expertise in complex designed and performed synthetic sequences.
    • Custom Chemistry Services are provided under a fee-for-service or an FTE model based on the needs of the customer.
    • Our team are technologically equipped to handle even the most challenging of reactions professionally and safely in transformations like: hydrogenation and catalysis knowledge, reductive alkylation, amidation, C-C and C-N cross coupling, oxidation, nitration, synthesis of N-heterocycles, photochemistry, methatesis, etc.
    • Our chemists, paired with our state-of-the-art flow reactors, provide a second to none combination of know-how and technology for quality custom synthesis of unique compounds with capabilities of -70-+1000°C and from vacuum to 400 bar.
    • The analytical team can provide complete analytical support, including NMR, HPLC, LCMS, preparative HPLC, GCMS, ICP, XRD, DTG, FT-IR, optical rotation. Upon request summary or publication-ready synthetic protocols are also provided.

    Main services for customers

    • Custom compound libraries
    • Compounds requiring complex
      multistep chemistry
    • Novel scaffold design and synthesis
    • DNA encoded library building blocks
    • Route scouting and retrosynthesis
    • Re-syntheses
    • Batch to flow process re-engineering
    • Chemistry problem solving and
      synthesis development
    • Scaffold-hopping and the design of new
      libraries around cores of interest

    FTE Based Custom Chemistry

    ComInnex provides either short or long-term collaborations with its partners for contracting full time equivalents work.

     

    FTEs are committed full time to the sponsor: a dedicated team works to a single customer with a reliable laboratory capacity.

    • Composition of the team depends on exact requirements and complexity of the chemistry (experienced supervisor for project management, additional PhD/MSc/BSc/technician chemist)

    High level of flexibility: Chemical or biological data may favor a new lead, target molecule(s) can be changed or modified any time (priority can also be varied). Intermediates or interesting by-products formed during the syntheses can be delivered upon request.

    Communication and Reporting:

    • Weekly or biweekly reports summarized in ppt slides based on ACS standards.
    • Discussions via weekly or biweekly video- or tele-conferences, yearly personal meetings (flexible) is a practice.
    • In-house developed electronic database allows clients to keep track of the work being carried out.
    • Final reports and protocols supplied in ready for publication or patenting forms.
    • Analytical files shared via electronic transfer (raw format is also available).
    • Compound structures shared (Sd files with enhanced stereochemistry) and electronic notebook sharing (Rd file) possible if needed. Printed lab notebooks supplied for request.
    • Communication and files shared via dedicated channels, FTP site or Share Point Site (supplied by either ComInnex or the Customer)

    Located in the EU: ComInnex has good access to all starting materials, moving goods to and from most of the countries does not present any problems.

    Delivery: Prepared compounds will be delivered in the requested packaging. Legal rights and CDA

    • Confidentiality, IP and legal rights will be comprehensively covered in the final contract.
    • All intellectual property belongs to the
      partner unless otherwise agreed.

     

    Consulting on ThalesNano flow instrumentation is also available.